Can the Apple M4 Max (128GB) run Qwen2.5 72B?

Yes
QuantQ8_0Near-lossless
Memory80.5 GBof 96 GB
Speed~4tokens/s

Yes. The Apple M4 Max (128GB) can run Qwen2.5 72B fully in unified memory at Q8_0 (near-lossless), using about 80.5 GB of the 96 GB available, at roughly 4 tokens/second.

Try other context lengths in the calculator →

Memory needed by quantization

At 8,192 tokens of context. macOS lets the GPU use about 96 GB of the 128 GB unified memory by default.

QuantQualityMemoryFits?Speed
FP16Full quality148.7 GBToo big—
Q8_0Near-lossless80.5 GBFits~4 tok/s
Q6_KExcellent62.9 GBFits~5 tok/s
Q5_K_MVery good55 GBFits~6 tok/s
Q4_K_MGood, most popular47.4 GBFits~7 tok/s
Q3_K_MNoticeably degraded38.8 GBFits~9 tok/s
Q2_KHeavily degraded30.5 GBFits~12 tok/s

How to run Qwen2.5 72B on the Apple M4 Max (128GB)

With Ollama installed, one command downloads and starts it:

ollama run qwen2.5:72b

Ollama's default download is Q4_K_M (about 47.4 GB here). You have room for Q8_0, which is near-lossless: pick that GGUF in LM Studio or from Hugging Face.

GPUs that run Qwen2.5 72B comfortably

Models that run well on the Apple M4 Max (128GB)

Run it in the cloud

Don't want to buy hardware? Run Qwen2.5 72B on a rented GPU today.

Rent a cloud GPU by the hour. No upfront cost, cancel any time.