Can the NVIDIA RTX 4060 run Mixtral 8x7B?

No

No. Even at Q4_K_M, Mixtral 8x7B needs about 30 GB, but the NVIDIA RTX 4060 has 8 GB usable. You could offload some layers to system RAM, but it will be very slow.

Try other context lengths in the calculator →
Run it in the cloud

Too big for the NVIDIA RTX 4060? Run Mixtral 8x7B on a rented GPU instead.

Rent a cloud GPU by the hour. No upfront cost, cancel any time.

Memory needed by quantization

At 8,192 tokens of context.

QuantQualityMemoryFits?Speed
FP16Full quality95.1 GBToo big—
Q8_0Near-lossless51.3 GBToo big—
Q6_KExcellent40 GBToo big—
Q5_K_MVery good34.9 GBToo big—
Q4_K_MGood, most popular30 GBToo big—
Q3_K_MNoticeably degraded24.5 GBToo big—
Q2_KHeavily degraded19.2 GBToo big—

How to run Mixtral 8x7B anyway

On a rented cloud GPU with enough memory, the same command you'd use locally works:

ollama run mixtral:8x7b

At Q4_K_M it needs about 30 GB, so pick a GPU with at least 32 GB.

GPUs that run Mixtral 8x7B comfortably

Check NVIDIA RTX 5090 prices →

Models that run well on the NVIDIA RTX 4060