Can the NVIDIA RTX 4080 run Llama 4 Scout 17B-16E?

No

No. Even at Q4_K_M, Llama 4 Scout 17B-16E needs about 68.3 GB, but the NVIDIA RTX 4080 has 16 GB usable. You could offload some layers to system RAM, but it will be very slow.

Try other context lengths in the calculator →
Run it in the cloud

Too big for the NVIDIA RTX 4080? Run Llama 4 Scout 17B-16E on a rented GPU instead.

Rent a cloud GPU by the hour. No upfront cost, cancel any time.

Memory needed by quantization

At 8,192 tokens of context.

QuantQualityMemoryFits?Speed
FP16Full quality220.2 GBToo big—
Q8_0Near-lossless118 GBToo big—
Q6_KExcellent91.6 GBToo big—
Q5_K_MVery good79.7 GBToo big—
Q4_K_MGood, most popular68.3 GBToo big—
Q3_K_MNoticeably degraded55.5 GBToo big—
Q2_KHeavily degraded43.1 GBToo big—

How to run Llama 4 Scout 17B-16E anyway

On a rented cloud GPU with enough memory, the same command you'd use locally works:

ollama run llama4:scout

At Q4_K_M it needs about 68.3 GB, so pick a GPU with at least 72 GB.

GPUs that run Llama 4 Scout 17B-16E comfortably

Models that run well on the NVIDIA RTX 4080