Can the NVIDIA RTX 5080 run Mistral 7B v0.3?

Yes
QuantQ8_0Near-lossless
Memory9.4 GBof 16 GB
Speed~75tokens/s

Yes. The NVIDIA RTX 5080 can run Mistral 7B v0.3 fully in VRAM at Q8_0 (near-lossless), using about 9.4 GB of the 16 GB available, at roughly 75 tokens/second.

Try other context lengths in the calculator →

Memory needed by quantization

At 8,192 tokens of context.

QuantQualityMemoryFits?Speed
FP16Full quality16.2 GBToo big—
Q8_0Near-lossless9.4 GBFits~75 tok/s
Q6_KExcellent7.6 GBFits~97 tok/s
Q5_K_MVery good6.8 GBFits~112 tok/s
Q4_K_MGood, most popular6.1 GBFits~131 tok/s
Q3_K_MNoticeably degraded5.2 GBFits~163 tok/s
Q2_KHeavily degraded4.4 GBFits~212 tok/s

How to run Mistral 7B v0.3 on the NVIDIA RTX 5080

With Ollama installed, one command downloads and starts it:

ollama run mistral:7b

Ollama's default download is Q4_K_M (about 6.1 GB here). You have room for Q8_0, which is near-lossless: pick that GGUF in LM Studio or from Hugging Face.

GPUs that run Mistral 7B v0.3 comfortably

Models that run well on the NVIDIA RTX 5080

Run it in the cloud

Don't want to buy hardware? Run Mistral 7B v0.3 on a rented GPU today.

Rent a cloud GPU by the hour. No upfront cost, cancel any time.