Can the NVIDIA RTX 5080 run Phi-3.5 Mini 3.8B?

Yes
QuantFP16Full quality
Memory11.5 GBof 16 GB
Speed~75tokens/s

Yes. The NVIDIA RTX 5080 can run Phi-3.5 Mini 3.8B fully in VRAM at FP16 (full quality), using about 11.5 GB of the 16 GB available, at roughly 75 tokens/second.

Try other context lengths in the calculator →

Memory needed by quantization

At 8,192 tokens of context.

QuantQualityMemoryFits?Speed
FP16Full quality11.5 GBFits~75 tok/s
Q8_0Near-lossless7.9 GBFits~142 tok/s
Q6_KExcellent7 GBFits~184 tok/s
Q5_K_MVery good6.5 GBFits~212 tok/s
Q4_K_MGood, most popular6.1 GBFits~249 tok/s
Q3_K_MNoticeably degraded5.7 GBFits~309 tok/s
Q2_KHeavily degraded5.3 GBFits~402 tok/s

How to run Phi-3.5 Mini 3.8B on the NVIDIA RTX 5080

With Ollama installed, one command downloads and starts it:

ollama run phi3.5:3.8b

Ollama's default download is Q4_K_M (about 6.1 GB here). You have room for FP16, which is full quality: pick that GGUF in LM Studio or from Hugging Face.

GPUs that run Phi-3.5 Mini 3.8B comfortably

Models that run well on the NVIDIA RTX 5080

Run it in the cloud

Don't want to buy hardware? Run Phi-3.5 Mini 3.8B on a rented GPU today.

Rent a cloud GPU by the hour. No upfront cost, cancel any time.